李赞，副教授，硕士生导师
个人简介
副教授，硕士生导师。2017年9月于南京大学配位化学国家重点实验室获得理学博士学位，2022年于南京大学生命分析化学国家重点实验室从事博士后研究（合作导师朱俊杰教授）。主要研究方向为肿瘤标志物检测和多模态诊疗体系开发，聚焦光响应探针的分子工程与生物医学应用研究，围绕活性氧物种（ROS）传感新机制和肿瘤靶向诊疗体系构建，以及活性药物可控递送开展系统性研究。以第一作者或通讯作者在 Angew. Chem. Int. Ed、Small、Biosensors and Bioelectronics、Analytical Chemistry 等学术期刊发表论文30余篇。Journal of Analysis and Testing (JAT) 期刊青年编委，主持山东省自然科学基金青年基金1项，参与国家自然科学基金、山东省重点研发计划各一项。
欢迎对生物分子传感分析、肿瘤光动力诊疗分子开发感兴趣的同学报考我的硕士研究生，同时欢迎具有强烈科研好奇心的本科生同学加入我们的研究团队开展科研训练项目,电子邮箱：[email protected]; [email protected]
教育背景
南京大学 分析化学 博士后 2022.03-2025.05
南京大学 无机化学 理学博士学位 2013.09-2017.09
江苏大学 应用化学 工学硕士学位 2010.09-2013.07
齐鲁工业大学 化学 理学学士学位 2006.09-2010.07
研究方向
（1）研究小分子与细胞相互作用以及肿瘤细胞定向作用药物；
（2）小分子荧光探针构筑及其对细胞内活性物种成像和定量分析；
（3）近红外诊疗分子构筑及其活体应用研究。
工作经历
2017/12-2021.12，曲阜师范大学，篮球比赛直播
，硕士生导师；
2021.12-至今，曲阜师范大学，篮球比赛直播
，副教授，硕士生导师。
承担本科生《分析化学》和《仪器分析》两门理论课的教学工作，承担本科生《基础分析实验》的实验教学工作，承担研究生《现代分析测试技术》理论课的教学工作。
科研项目
（1）激活型近红外II区诊疗分子构建及其对乏氧肿瘤成像研究，2021.01-2023.12，主持，已结题，山东省自然科学基金，ZR2020QB149，15万元；
（2）曲阜师范大学科研启动基金，项目号612601，在研，20万元；
（3）同型半胱氨酸荧光探针的设计合成与生物学应用，2015.05-2016.06，主持，已结题，江苏省普通高校学术学位研究生创新计划，KYZZ15_0030，3万元。
（4）基于稳定同位素辅助的组学技术对透明质酸发酵的关键技术研究，2021.12-2025.12，主要研究人员，山东省重点研发计划，2021ZDSYS23，181万。
发表论文
[1] Xie Xiunan, Lu Zhihao, Kong Yuerui, Jin Chenye, Sun Ziyan, Yang Xiaoling, Li Zan*, Qu Fengli* Tan Weihong. Ferroptosis-Impelled NIR Cyanine Dyes in Situ Generation Enabled Zero-Background Fluorescence Imaging and Precise Surgical Tumor Excision. Angew. Chem. Int. Ed., 2025, e20221.
[2] Li Zan*, Xie Xiunan, Lu Zhihao, Zhang Yifan, Kong Yuerui, You Jinmao, Zhu Jun-Jie*. Albumin Modulated Homodimer as an Efficient Photosensitizer for Long-Term Imaging-Guided Tumor Therapy Directed with Sunlight Irradiation. Small, 2025, 21, 2411736.
[3] Lu Zhihao, Tan Jiangkun, Wu Yuting, You Jinmao*, Xie Xiunan, Zhang Zhiyong, Li Zan*, Chen Lingxin*. NIR Light-Activated Mitochondrial RNA Cross-Linking Strategy for H2S Monitoring and Prolonged Colorectal Tumor Imaging. Anal. Chem., 2023, 95, 17089−17098.
[4] Zhang Zhiyong, Gao Chunyu, Lu Zhihao, Xie Xiunan, You Jinmao, Li Zan*. Sunlight-directed fluorophore-switch in photosynthesis of cyanine subcellular organelle markers for bio-imaging. Biosens. Bioelectron., 2023, 237, 115485.
[5] Li Zan*, Tan Jiangkun, Gao Chunyu, Lu Zhihao, You Jinmao, Zhu Jun-Jie*. Polarity-Ultrasensitive and Lipophilicity-Enhanced Structurally Modified Hemicyanine for Two-Color Staining to Reveal Cell Apoptosis during Chemotherapy. Anal. Chem., 2023, 95, 2011–2019.
[6] Tan Jiangkun, Lu Zhihao, Gao Chunyun, Zhang Zhuoyue, Sun Ziyan, Ling Baoping*, Li Zan*, You Jinmao*. Electronic tuning strategy in H2S-triggered fluorescence sensing and subsequent photodynamic therapy of colon cancer. Dyes Pigments, 2023, 213, 111199.
[7] Zhang Zhiyong, Lu Zhihao*, Zou Xiaocong, Xie Xiunan, You Jinmao, Li Zan*. Discrimination of aniline and benzaldehyde assisted with Fisher’s base. New J. Chem., 2024, 48, 1057–1061.
[8] Ding Jie, Kang Xing, Feng Min, Tan Jiangkun, Feng Qingzhao, Wang Xingzhou, Wang Jiafeng, Liu Jiang, Li Zan*, Guan Wenxian*, Qiao Tong*. A novel active mitochondrion-selective fluorescent probe for the NIR fluorescence imaging and targeted photodynamic therapy of gastric cancer. Biomater. Sci., 2022, 10, 4756–4763.
[9] Gao Chunyu, Ding Ziyi, Tan Jiangkun, You Jinmao*, Li Zan*. Homocysteine-specific fluorescence detection and quantification for evaluating S-adenosylhomocysteine hydrolase activity. Analyst, 2022, 147, 3675–3683.
[10] Li Zan*, Lu Jiao, Pang Qing, You Jinmao*. Construction of a near-infrared fluorescent probe for ratiometric imaging of peroxynitrite during tumor progression. Analyst, 2021, 146, 5204-5211.
[11] Tan Jiangkun, Li Zan*, Yao Wen, Ji Zhongyin, Sun Zhiwei, You Jinmao*. Construction of ultrasensitive devices for visualization and quantification of phosgene based on FRET-mediated two-photon chemosensor. Dyes Pigments, 2021, 187, 109138.
[12] Tan Jiangkun, Li Zan*, Lu Zhihao, Chang Rui, Sun Zhiwei, You Jinmao*. Recent progress in the development of chemodosimeters for fluorescence visualization of phosgene. Dyes Pigments, 2021, 193, 109540.
[13] Lu Jiao, Li Zan*, Gao Qing, Tan Jiangkun, Sun Zhiwei, Chen Lingxin*, You Jinmao*. Nonoxidative Strategy for Monitoring Peroxynitrite Fluctuations in Immune Responses of Tumorigenesis. Anal. Chem., 2021, 93, 3426–3435.
[14] Gao Yue, Tan Jiangkun, Lu Jiao, Sun Zhiwei, Li Zan*, Ji Zhongyin, Zhang Shijuan, You Jinmao*. A novel fluorescent labeling reagent, 2-(9-acridone)-ethyl chloroformate, and its application to the analysis of free amino acids in honey samples by HPLC with fluorescence detection and identification with online ESI-MS. Anal. Bioanal. Chem., 2020, 412, 8339–8350.
[15] Lu Jiao, Li Zan*, Zheng Xinrui, Tan Jiangkun, Ji Zhongyin, Sun Zhiwei, You Jinmao*. A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model, J. Mater. Chem. B., 2020, 8, 9343–9350.
[16] Li Zan*, Zhu Zhenzhu, Sun Zhiwei, Ding Jie, You Jinmao*. Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels. Sens. Actuators, B. Chemical, 2019, 282, 541–548.
[17] Li Zan, Guo Taiyu, Lu Jiao, Wang Zheng, Zhang Miaomiao, Geng Zhirong*, Wang Zhilin*. Targeted copper supplementation oriented theranostic for fluorescence and 19F NMR detection of tumors. Chem. Commun., 2020, 56, 11589–11592.
[18] Li Zan, Ding Jie, Chen Chunxia, Chang Jiayin, Geng Zhirong*. Huang Binghuan, Wang Zhilin*. Dual-target Cancer Theranostic for Glutathione S-Transferase and Hypoxia-inducible Factor-1 α Inhibition. Chem. Commun., 2017, 53, 12406–12409.
[19] Li Zan, Yan Shihai, Chen Chen, Geng Zhirong*, Wang Zhilin*. Molecular visualizing and quantifying immune-associated peroxynitrite fluxes in phagocytes and mouse inflammation model. Biosens. Bioelectron., 2017, 90, 75–82.
[20] Li Zan, Geng Zhirong*, Zhang Cui, Wang Xiaobo, Wang Zhilin*. BODIPY-based azamacrocyclic ensemble for selective fluorescence detection and quantification of homocysteine in biological applications. Biosens. Bioelectron., 2015, 72, 1–9.
[21] Li Zan, Chen Qiuyun*, Wang Peidong, Wu Yi. Multifunctional BODIPY Derivatives to Image Cancer Cells and Sense Copper(II) Ions in Living Cells. RSC Adv., 2013, 3, 5524–5528.
